Obstructive sleep apnea and comorbidities: a dangerous liaison

  • Maria R. Bonsignore | marisa@ibim.cnr.it Division of Respiratory Medicine, Biomedical Department of Internal Medicine and Medical Specialties (Di.Bi.M.I.S), University Hospital Paolo Giaccone, University of Palermo, Palermo; National Research Council (CNR), Institute of Biomedicine and Molecular Immunology (IBIM), Palermo, Italy.
  • Pierpaolo Baiamonte Division of Respiratory Medicine, Biomedical Department of Internal Medicine and Medical Specialties (Di.Bi.M.I.S), University Hospital Paolo Giaccone, University of Palermo, Palermo, Italy.
  • Emilia Mazzuca Division of Respiratory Medicine, Biomedical Department of Internal Medicine and Medical Specialties (Di.Bi.M.I.S), University Hospital Paolo Giaccone, University of Palermo, Palermo, Italy.
  • Alessandra Castrogiovanni Clinic for Pneumology und Allergology, Center of Sleep Medicine and Respiratory Care, Bethanien Hospital, Solingen, Germany.
  • Oreste Marrone National Research Council (CNR), Institute of Biomedicine and Molecular Immunology (IBIM), Palermo, Italy.

Abstract

Obstructive sleep apnea (OSA) is a highly prevalent disease, and is traditionally associated with increased cardiovascular risk. The role of comorbidities in OSA patients has emerged recently, and new conditions significantly associated with OSA are increasingly reported. A high comorbidity burden worsens prognosis, but some data suggest that CPAP might be protective especially in patients with comorbidities. Aim of this narrative review is to provide an update on recent studies, with special attention to cardiovascular and cerebrovascular comorbidities, the metabolic syndrome and type 2 diabetes, asthma, COPD and cancer. Better phenotypic characterization of OSA patients, including comorbidities, will help to provide better individualized care. The unsatisfactory adherence to CPAP in patients without daytime sleepiness should prompt clinicians to examine the overall risk profile of each patient in order to identify subjects at high risk for worse prognosis and provide the optimal treatment not only for OSA, but also for comorbidities.

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Published
2019-02-14
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Issue
Section
Reviews
Keywords:
Mortality, prognosis, cardiovascular disease, diabetes, asthma, COPD, cancer
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How to Cite
Bonsignore, M. R., Baiamonte, P., Mazzuca, E., Castrogiovanni, A., & Marrone, O. (2019). Obstructive sleep apnea and comorbidities: a dangerous liaison. Multidisciplinary Respiratory Medicine, 14(1). https://doi.org/10.4081/mrm.2019.10