Extravascular lung water and pulmonary arterial wedge pressure for fluid management in patients with acute respiratory distress syndrome

  • Wei Hu | weihucn@126.com Department of Intensive Care Unit, the First People’s Hospital of Hangzhou, Nanjing Medical University, Hangzhou, China.
  • Chang-Wen Lin Department of Intensive Care Unit, the First People’s Hospital of Hangzhou, Nanjing Medical University, Hangzhou, China.
  • Bing-Wei Liu Department of Intensive Care Unit, the First People’s Hospital of Hangzhou, Nanjing Medical University, Hangzhou, China.
  • Wei-Hang Hu Department of Intensive Care Unit, the First People’s Hospital of Hangzhou, Nanjing Medical University, Hangzhou, China.
  • Ying Zhu Department of Intensive Care Unit, the First People’s Hospital of Hangzhou, Nanjing Medical University, Hangzhou, China.

Abstract

Background: Extravascular lung water (EVLW) is a sensitive prognostic indicator of pulmonary edema. Thus, EVLW may be an advantageous method of fluid management. This study aims to evaluate the outcomes of using EVLW and pulmonary artery wedge pressure (PAWP) as strategies for fluid management in patients with acute respiratory distress syndrome (ARDS).

Methods: Twenty-nine patients were randomly divided into the EVLW and PAWP groups. The survival rate, ICU (Intensive Care Unit) length of stay, duration of mechanical ventilation, acute lung injury scores, and oxygenation index of the EVLW and PAWP groups were compared.

Results: No significant difference in the survival rates at 28 and 60 days (d) after treatment was found between the two groups (p = 0.542). The duration of mechanical ventilation and ICU length of stay were significantly lower (p<0.05) in the EVLW group than in the PAWP group. The 7 d cumulative fluid balance was −783 ± 391 ml in the EVLW group and −256 ± 514 ml in the PAWP group (p < 0.05). Compared with the PAWP group, the EVLW group showed improved oxygenation index (p = 0.006).

Conclusions: EVLW for fluid management improved clinical results in patients with ARDS better than PAWP.

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Published
2014-01-16
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Original Research Articles
Keywords:
Acute respiratory distress syndrome, Extravascular lung water, Fluid management, Pulmonary artery wedge pressure
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How to Cite
Hu, W., Lin, C.-W., Liu, B.-W., Hu, W.-H., & Zhu, Y. (2014). Extravascular lung water and pulmonary arterial wedge pressure for fluid management in patients with acute respiratory distress syndrome. Multidisciplinary Respiratory Medicine, 9(1). https://doi.org/10.4081/mrm.2014.360