Increased circulating obestatin in patients with chronic obstructive pulmonary disease

  • Yi Lei Department of Family Medicine, West China Hospital, Sichuan University, Chengdu, China.
  • Yasha Liang Department of Family Medicine, West China Hospital, Sichuan University, Chengdu, China.
  • Xiaojing Liu Department of Family Medicine, West China Hospital, Sichuan University, Chengdu, China.
  • Xiaoyang Liao | xiaoyangliao@hotmail.com Department of Family Medicine, West China Hospital, Sichuan University, Chengdu, China.
  • Fengming Luo Department of Family Medicine, West China Hospital, Sichuan University, Chengdu, China.

Abstract

Background: Some peptides, which regulate the metabolic balance, are thought to play important roles in nutritional disorders and systemic inflammation in COPD. Treatment of rats with obestatin decreased body-weight gain. Obestatin was also found to be correlated with inflammation in rheumatoid arthritis. The aims of this study were to investigate the level of circulating obestatin in COPD and to analyze the relationship among obestatin and nutritional status, and systemic inflammation.

Methods: 32 COPD patients with BMI less than 20 kg/m2 and 22 normal controls were included. Body composition was estimated using “foot-to-foot” BIA technology. Circulating obestatin was determined with enzyme-linked immunosorbent assay. Pulmonary function, TNF-α and C reactive protein were also measured.

Results: The level of circulating obestatin was higher in COPD with underweight than that in normal control (5562.75 ± 3435.43 pg/ml in COPD, 3663.90 ± 2313.95 pg/ml in controls, p = 0.028). BMI, Waist circumference, hip circumference, bodyFAT and FAT% in COPD group were lower than those in normal control. Positive correlation was found among circulating C reactive protein, TNF-α and obestatin. There was no significant correlation among BMI, pulmonary function and obestatin.

Conclusions: This study shows that circulating obestatin is higher in underweight COPD patients, and positively correlated to systemic inflammation, but not to nutritional status.

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Author Biographies

Yi Lei, Department of Family Medicine, West China Hospital, Sichuan University, Chengdu

†Equal contributors

Yasha Liang, Department of Family Medicine, West China Hospital, Sichuan University, Chengdu

†Equal contributors

Published
2014-01-28
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Original Research Articles
Keywords:
COPD, Inflammation,, Nutrition, Obestatin
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How to Cite
Lei, Y., Liang, Y., Liu, X., Liao, X., & Luo, F. (2014). Increased circulating obestatin in patients with chronic obstructive pulmonary disease. Multidisciplinary Respiratory Medicine, 9(1). https://doi.org/10.4081/mrm.2014.362