Evaluation of reactive oxygen metabolites in patients with non-small cell lung cancer after chemotherapy

  • Toru Wakabayashi Department of Internal Medicine, Toho University Sakura Medical Center, Chiba, Japan.
  • Tatsuo Kawashima | t-kawashima@sakura.med.toho-u.ac.jp Department of Internal Medicine, Toho University Sakura Medical Center, Chiba, Japan.
  • Yasuo Matsuzawa Department of Internal Medicine, Toho University Sakura Medical Center, Chiba, Japan.

Abstract

Background: The aim of this study was to evaluate the level of reactive oxygen metabolites (ROMs) after chemotherapy in patients with non-small cell lung cancer (NSCLC) and its association with response to treatment.

Methods: Fifty-eight untreated NSCLC patients and twenty-three healthy subjects were selected for the study. Patients received two courses of platinum-based chemotherapy and were evaluated for oxidative stress and treatment response. As a marker of reactive oxygen species, ROMs levels were measured using the d-ROMs test.

Results: ROMs level (mean ± standard deviation) before chemotherapy in NSCLC patients (416 ± 135 U.CARR) was significantly elevated (p = 0.016) compared to normal healthy subjects (320 ± 59 U.CARR). Patients who responded to chemotherapy showed significantly decreased (p = 0.014) ROMs levels after chemotherapy, whereas patients who had stable disease or progressive disease showed no change in ROMs level (p = 0.387).

Conclusions: NSCLC patients had significantly elevated ROMs levels before chemotherapy compared with normal healthy subjects. Chemotherapy may suppress ROMs production in responders but not in non-responders. ROMs level may be a predictor of clinical outcome in patients receiving chemotherapy for NSCLC.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2014-08-29
Info
Issue
Section
Original Research Articles
Keywords:
Chemotherapy, Lung cancer, Oxidative stress, Reactive oxygen metabolites, Reactive oxygen species
Statistics
  • Abstract views: 102

  • PDF: 70
  • HTML: 12
How to Cite
Wakabayashi, T., Kawashima, T., & Matsuzawa, Y. (2014). Evaluation of reactive oxygen metabolites in patients with non-small cell lung cancer after chemotherapy. Multidisciplinary Respiratory Medicine, 9(1). https://doi.org/10.4081/mrm.2014.379