The association of human leukocyte antigen polymorphisms with disease severity and latency period in patients with silicosis

  • Hasan Dogan | dthdogan@gmail.com Medical Biology Department, Faculty of Medicine, Ataturk University, Erzurum, Turkey, Turkey.
  • Metin Akgun Chest Diseases Department and Pulmonary Diseases Department, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
  • Omer Araz Chest Diseases Department and Pulmonary Diseases Department, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
  • Elif Yilmazel Ucar Chest Diseases Department and Pulmonary Diseases Department, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
  • Ozgur Yoruk Otorhinolaryngology Department, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
  • Eda Diyarbakir Medical Biology Department, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
  • Omer Atis Medical Biology Department, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
  • Fatih Akdemir Medical Biology Department, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
  • Hamit Acemoglu4 Medical Education Department, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
  • Ibrahim Pirim Medical Biology and Genetics Department, Faculty of Medicine, Katip Celebi University, Izmir, Turkey.

Abstract

Background: Denim sandblasting may cause silicosis as a result of free crystalline silica inhalation. Its pathogenesis remains unclear, but autoimmunity may play a role in the development of silicosis. The present study aimed to investigate the relationships between human leukocyte antigen (HLA) and the severity and latency period of silicosis.

Methods: 48 silicotic patients in the Eastern part of Turkey were classified according to their latency period and disease severity. The distribution of HLAs according to disease severity and latency period was assessed.

Results: A23 (7.5%), B49 (7.5%), and B51 (25%) were more common in the mild group than in the severe group, and B55 (8.9%) and DR4 (17.9%) were more common in the severe group than in the mild one. Only B51 was significantly more common in the mild group than in the severe one (25%, n = 10 vs. 7.1%, n = 4; p = 0.016).

Conclusions: This study suggests that HLA antigens may play a particular role in the severity of silica-induced lung disease, but there was no association between HLA and progression time of the disease.

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Published
2014-03-19
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Original Research Articles
Keywords:
HLA polymorphism, Immunity, Latency, Severity, Silicosis
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How to Cite
Dogan, H., Akgun, M., Araz, O., Ucar, E. Y., Yoruk, O., Diyarbakir, E., Atis, O., Akdemir, F., Acemoglu4H., & Pirim, I. (2014). The association of human leukocyte antigen polymorphisms with disease severity and latency period in patients with silicosis. Multidisciplinary Respiratory Medicine, 9(1). https://doi.org/10.4081/mrm.2014.418