The use of exhaled nitric oxide and peak expiratory flow to demonstrate improved breathability and antimicrobial properties of novel face mask made with sustainable filter paper and Folium Plectranthii amboinicii oil: additional option for mask shortage during COVID-19 pandemic

  • Sy Duong-Quy | sduongquy.jfvp@gmail.com Medical-Biological Research Center, Lamdong Medical College, Da Lat city, Viet Nam.
  • Xuan Ngo-Minh Pham Ngoc Thach Medical University, Ho Chi Minh city, Viet Nam.
  • Trinh Tang-Le-Quynh Medical-Biological Research Center, Lamdong Medical College, Da Lat city, Viet Nam.
  • Tram Tang-Thi-Thao Medical-Biological Research Center, Lamdong Medical College, Da Lat city, Viet Nam.
  • Bao Nguyen-Quoc Medical-Biological Research Center, Lamdong Medical College, Da Lat city, Viet Nam.
  • Khiet Le-Quang Medical-Biological Research Center, Lamdong Medical College, Da Lat city, Viet Nam.
  • Dinh Tran-Thanh Medical-Biological Research Center, Lamdong Medical College, Da Lat city, Viet Nam.
  • Nhu Doan-Thi-Quynh Medical-Biological Research Center, Lamdong Medical College, Da Lat city, Viet Nam.
  • Ethan Canty Division of Immuno-Allergology, Hershey Medical Center, Penn State Medical College, Hershey, PA, United States. https://orcid.org/0000-0003-2711-7527
  • Toan Do Division of Immuno-Allergology, Hershey Medical Center, Penn State Medical College, Hershey, PA, United States. https://orcid.org/0000-0002-9098-4538
  • Timothy Craig Division of Immuno-Allergology, Hershey Medical Center, Penn State Medical College, Hershey, PA, United States.

Abstract

Background: Medical face masks are integral personal protective equipment against infectious airborne disease and become scarce during epidemic outbreaks such as COVID-19. A novel, sustainably manufactured face mask with antimicrobial and anti-inflammatory properties from oil of Folium Plectranthii amboinicii can be an effective alternative to internationally sold masks. Methods: This prospective, randomized study assigned subjects (n=67) to either conventional surgical face mask or Lamdong Medical College (LMC) face mask for three hours. Fractional concentration of nitric oxide in exhaled breath (FENO) and peak expiratory flow (PEF) was measured before and after mask use. Subjective reporting on respiratory symptoms was also analyzed. Masks were then incubated and analyzed for microorganism growth. Results: Subjects assigned the LMC mask had a lowered FENO (p<0.05) compared to conventional face masks after mask wearing. Subjects with LMC mask use reported higher comfortability (p<0.05), breathability (p<0.05), and lower allergy symptoms (p<0.05). The LMC mask has visually less microorganism growth in the cultured medium, measured by sterile ring radius. Conclusions: The LMC face mask is a renewably manufactured personal protective tool with antibacterial capacity that can serve as an effective alternative to internationally sold surgical face mask during shortage of mask due to COVID-19.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Author Biography

Sy Duong-Quy, Medical-Biological Research Center, Lamdong Medical College, Da Lat city

Division of Immuno-Allergology, Hershey Medical Center, Penn State Medical College, Hershey, PA, USA; Pham Ngoc Thach Medical University, Ho Chi Minh city, Vietnam

References

Zhou SS, Lukula S, Chiossone C, Nims RW, Suchmann DB, Ijaz MK. Assessment of a respiratory face mask for capturing air pollutants and pathogens including human influenza and rhinoviruses. J Thorac Dis 2018;10:2059-69. DOI: https://doi.org/10.21037/jtd.2018.03.103

Cowling BJ, Zhou Y, Ip DKM, Leung GM, Aiello AE. Face masks to prevent transmission of influenza virus: a systematic review. Epidemiol Infect 2010;138:449-56. DOI: https://doi.org/10.1017/S0950268809991658

Smith JD, Macdougall CC, Johnstone J, Copes RA, Schwartz B, Garber GE. Effectiveness of N95 respirators versus surgical masks in protecting health care workers from acute respiratory infection: a systematic review and meta-analysis. CMAJ 2016;188:567-74. DOI: https://doi.org/10.1503/cmaj.150835

Carias C, Rainisch G, Shankar M, et al. Potential demand for respirators and surgical masks during a hypothetical influenza pandemic in the United States. Clin Infect Dis 2015;60:S42-51. DOI: https://doi.org/10.1093/cid/civ141

Truong-Thanh T, Tran Thi Minh T, Tang Thi Thao T, Tang Le Quynh T. Study the effect of Plectranthii amboinicii’s tea in treatment of acute bronchitis. J Funct Vent Pulmonol 2019;10:36-40. DOI: https://doi.org/10.12699/jfvpulm.10.31.2019.36

Tang-Le-Quynh T, Ngo-Duy-Tuy H, Mai-Thanh K, Tran-Thanh D, Tran-Ngoc T, Le-Quang K, et al. Study of active compounds of Plectranthii Amboinicii leaves growing in Dalat City, Vietnam and its antibacterial and antioxidant activities. World J Pharm Pharm Sci 2017;6:77-94.

Tiwari D, Nagar H, Dwivedi G, Tripathi R, Jena J. Evaluation of anti-anxiety activity of Plectranthus amboinicus (Lour.) on rats. Asian J Pharm Clin Res 2012;5:110-3.

Pillai PG, Suresh P, Aggarwal G, Doshi G, Bhatia V. Pharmacognostical standardization and toxicity profile of the methanolic leaf extract of Plectranthus amboinicus (Lour) Spreng. J Appl Pharm Sci 2011;1:76-81.

Manjamalai A, Alexander T, Berlin Grace VM. Bioactive evaluation of the essential oil of plectranthus amboinicus by GC-MS analysis and its role as a drug for microbial infections and inflammation. Int J Pharm Pharm Sci 2012;4:S205-11.

Selvakumar P, Naveena BE, Prakash SD. Studies on the antidandruff activity of the essential oil of coleus amboinicus and eucalyptus globulus. Asian Pacific J Trop Dis 2012;2:S715-9. DOI: https://doi.org/10.1016/S2222-1808(12)60250-3

Galvão Rodrigues FF, Costa JGM, Rodrigues FFG, Campos AR. Study of the interference between plectranthus species essential oils from Brazil and aminoglycosides. Evid Based Complement Altern Med 2013;2013:724161. DOI: https://doi.org/10.1155/2013/724161

Duong-Quy S. Clinical utility of the exhaled nitric oxide (NO) measurement with portable devices in the management of allergic airway inflammation and asthma. J Asthma Allergy 2019;12:331-41. DOI: https://doi.org/10.2147/JAA.S190489

Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med 2011;184:602-15. DOI: https://doi.org/10.1164/rccm.9120-11ST

Heffler E, Carpagnano GE, Favero E, Guida G, Maniscalco M, Motta A, et al. Fractional Exhaled Nitric Oxide (FENO) in the management of asthma: a position paper of the Italian Respiratory Society (SIP/IRS) and Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC). Multidiscip Respir Med 2020;15:36. DOI: https://doi.org/10.4081/mrm.2020.36

Tsurikisawa N, Oshikata C, Sato T, Kimura G, Mizuki M, Tsuburai T, et al. Low variability in peak expiratory flow predicts successful inhaled corticosteroid step-down in adults with asthma. J Allergy Clin Immunol Pract 2018;6:972-9. DOI: https://doi.org/10.1016/j.jaip.2017.10.036

Eninger RM, Honda T, Adhikari A, Heinonen-Tanski H, Reponen T, Grinshpun SA. Filter performance of N99 and N95 facepiece respirators against viruses and ultrafine particles. Ann Occup Hyg 2008;52:385-96. DOI: https://doi.org/10.1093/annhyg/men019

Grinshpun SA, Haruta H, Eninger RM, Reponen T, McKay RT, Lee SA. Performance of an N95 filtering facepiece particulate respirator and a surgical mask during human breathing: Two pathways for particle penetration. J Occup Environ Hyg 2009;6:593-603. DOI: https://doi.org/10.1080/15459620903120086

Lee S, Grinshpun SA, Reponen T. Respiratory performance offered by N95 respirators and surgical masks: Human subject evaluation with NaCl aerosol representing bacterial and viral particle size range. Ann Occup Hyg 2008;52:177-85. DOI: https://doi.org/10.1093/annhyg/men005

Oberg T, Brosseau LM. Surgical mask filter and fit performance. Am J Infect Control 2008;36:276-82. DOI: https://doi.org/10.1016/j.ajic.2007.07.008

Dinh-Thi-Dieu H, Vo-Thi-Kim A, Tran-Van H, Tang-Thi-Thao T, Duong-Quy S. Study of the beneficial role of exhaled nitric oxide in combination with GINA guidelines for titration of inhaled corticosteroids in children with asthma. J Breath Res 2020;14:026014. DOI: https://doi.org/10.1088/1752-7163/ab6809

Davies A, Thompson K-A, Giri K, Kafatos G, Walker J, Bennett A. Testing the efficacy of homemade masks: would they protect in an influenza pandemic? Disaster Med Public Health Prep 2013;7:413-8. DOI: https://doi.org/10.1017/dmp.2013.43

Wang X, Zhang X, He J. Challenges to the system of reserve medical supplies for public health emergencies: reflections on the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in China. Biosci Trends 2020;14:3-8. DOI: https://doi.org/10.5582/bst.2020.01043

Published
2020-06-01
Info
Issue
Section
Original Research Articles
Keywords:
Filter paper mask, Folium Plectranthii amboinicii, Covid-19, pandemic, mask shortage
Statistics
  • Abstract views: 1413

  • PDF: 482
  • HTML: 0
How to Cite
Duong-Quy, S., Ngo-Minh, X., Tang-Le-Quynh, T., Tang-Thi-Thao, T., Nguyen-Quoc, B., Le-Quang, K., Tran-Thanh, D., Doan-Thi-Quynh, N., Canty, E., Do, T., & Craig, T. (2020). The use of exhaled nitric oxide and peak expiratory flow to demonstrate improved breathability and antimicrobial properties of novel face mask made with sustainable filter paper and <em>Folium Plectranthii amboinicii</em&gt; oil: additional option for mask shortage during COVID-19 pandemic. Multidisciplinary Respiratory Medicine, 15. https://doi.org/10.4081/mrm.2020.664