Feasibility, utility, and safety of transbronchial cryobiopsy for interstitial lung diseases in Japan

Takato Ikeda; Akira Nakao; Fumiyasu Igata; Yoshiaki Kinoshita; Hisako Kushima; Takemasa Matsumoto; Hiroshi Ishii; Kazuki Nabeshima; Masaki Fujita

doi:10.4081/mrm.2021.731

Feasibility, utility, and safety of transbronchial cryobiopsy for interstitial lung diseases in Japan

Authors

Takato Ikeda Department of Respiratory Medicine, Fukuoka University Hospital, Jonanku, Fukuoka https://orcid.org/0000-0003-3300-6225
Akira Nakao Department of Respiratory Medicine, Fukuoka University Hospital, Jonanku, Fukuoka
Fumiyasu Igata Department of Respiratory Medicine, Fukuoka University Hospital, Jonanku, Fukuoka
Yoshiaki Kinoshita Department of Respiratory Medicine, Fukuoka University Chikushi-Hospital, Chikushino
Hisako Kushima Department of Respiratory Medicine, Fukuoka University Chikushi-Hospital, Chikushino
Takemasa Matsumoto Department of Respiratory Medicine, Fukuoka University Hospital, Jonanku, Fukuoka
Hiroshi Ishii Department of Respiratory Medicine, Fukuoka University Chikushi-Hospital, Chikushino
Kazuki Nabeshima Department of Pathology, Fukuoka University Hospital, Jonanku, Fukuoka
Masaki Fujita Department of Respiratory Medicine, Fukuoka University Hospital, Jonanku, Fukuoka https://orcid.org/0000-0003-1209-1272

DOI: https://doi.org/10.4081/mrm.2021.731

Keywords:

transbronchial lung cryobiopsy, transbronchial lung biopsy, interstitial lung disease, idiopathic pulmonary fibrosis

Abstract

Background: Transbronchial lung cryobiopsy (TBLC) is a new technique that enables larger tissue collection than can be obtained by conventional transbronchial lung biopsy. TBLC is becoming popular worldwide and is performed for diffuse lung disease and lung cancer. However, only a few reports of TBLC have been published in Japan. This study was performed to evaluate the efficacy and safety of TBLC at our hospital and compare these findings with past reports.
Methods: From April 2018 to January 2020, 38 patients who underwent TBLC for diffuse lung disease at our hospital were evaluated with respect to age, sex, biopsy site, biopsy size, diagnostic disease, and complications.
Results: The patients who underwent TBLC constituted 20 men and 18 women with an average age of 63.7 years. The average sample size was 5.7 mm, and the diagnostic rate was 65.7% (25/38). Grade ≥2 complications included bleeding (15.8%), pneumothorax (2.6%), and atrial fibrillation (2.6%).
Conclusions: TBLC was considered to be useful for the diagnosis of diffuse lung disease and could be safely performed.

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