When sarcoidosis hits down: a case of prostatic sarcoidosis

When sarcoidosis hits down: a case of prostatic sarcoidosis

Authors

  • Antonio Moretti Respiratory Diseases Unit and Centre for Rare Lung Diseases, University Hospital of Modena https://orcid.org/0000-0002-4386-746X
  • Giulia Bruzzi Respiratory Diseases Unit and Centre for Rare Lung Diseases, University Hospital of Modena (Italy) https://orcid.org/0000-0002-5702-0390
  • Dario Andrisani Respiratory Diseases Unit and Centre for Rare Lung Diseases, University Hospital of Modena (Italy)
  • Filippo Gozzi Respiratory Diseases Unit and Centre for Rare Lung Diseases, University Hospital of Modena (Italy)
  • Matteo Costantini Pathology Unit, University Hospital of Modena (Italy)
  • Roberto Tonelli Respiratory Diseases Unit and Centre for Rare Lung Diseases, University Hospital of Modena (Italy) https://orcid.org/0000-0002-6202-0758
  • Enrico Clini Respiratory Diseases Unit and Centre for Rare Lung Diseases, University Hospital of Modena (Italy) https://orcid.org/0000-0002-1515-5094
  • Stefania Cerri Respiratory Diseases Unit and Centre for Rare Lung Diseases, University Hospital of Modena (Italy) https://orcid.org/0000-0003-4612-1580

Keywords:

Sarcoidosis, prostate, urogenital involvement of sarcoidosis

Abstract

A 69-year-old North African male with established diagnosis of sarcoidosis underwent a stereotactic prostate biopsy with fusion technique. At the histological analysis, non-necrotizing micro-granulomas were highlighted in 2 samples, while the immunohistochemical staining resulted negative for CK903/p63/racemase. To the best of our knowledge, only 16 cases of prostatic sarcoidosis have been reported in literature. With this case report we describe an incidental diagnosis of prostatic involvement of sarcoidotic disease and briefly review and discuss the available literature on the topic.

References

Crouser ED, Maier LA, Wilson KC, Bonham CA, Morgenthau, AS, Patterson, KC, et al. Diagnosis and Detection of Sarcoidosis. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2020 Apr 15;201:e26–51. doi: 10.1164/rccm.202002-0251ST

La Rochelle JC and Coogan CL. Urological Manifestations of Sarcoidosis. J Urol. 2012 Jan;187:18–24. doi: 10.1016/j.juro.2011.09.057

Kodama K, Hasegawa T, Egawa M, Tomosugi N, Mukai A, and Namiki M. Bilateral epididymal sarcoidosis presenting without radiographic evidence of intrathoracic lesion: Review of sarcoidosis involving the male reproductive tract. Int J Urol Off J Jpn Urol Assoc. 2004 May;11:345–8. doi: 10.1111/j.1442-2042.2004.00783.x

Block NL and Kava BR. Genitourinary sarcoidosis: An essential review for the practicing clinician. Indian J Urology. 2017;33:6–12. doi: 10.4103/0970-1591.195724

Furusato B, Koff S, McLeod DG, and Sesterhenn IA. Sarcoidosis of the prostate. J Clin Pathol. 2007 Mar 1;60:325–6. doi: 10.1136/jcp.2006.039222

Mulpuru SK, Gujja K, Pai VM, Chen CYY, and Levey RL. A rare and unusual cause of PSA (prostate-specific antigen) elevation: sarcoidosis of the prostate. Am J Med Sci. 2008 Mar;335:246–8. doi: 10.1097/MAJ.0b013e31811eba71

Maurice MJ and Zhu H. Sarcoidosis of the prostate. J Urol. 2013 Aug;190:711–2. doi: 10.1016/j.juro.2013.05.017

Osanami A, Yamashita T, Sakurada S, Kyoda, Y, Shindo, T, et al. Systemic sarcoidosis presenting as a rare combination of interstitial nephritis with necrotizing vasculitis and urinary retention due to prostate involvement: a case report. BMC Nephrol. 2023 Dec 13;24:370. doi: 10.1186/s12882-023-03430-9

McCormick ME and Pewitt EB. Careful consideration of sarcoidosis in diagnosis and staging of prostate cancer: A case report. Urol Case Rep. 2022 Nov;45:102255. doi: 10.1016/j.eucr.2022.102255

.

Downloads

Published

09-04-2024

Issue

Section

Case Reports

How to Cite

“When Sarcoidosis Hits Down: A Case of Prostatic Sarcoidosis”. 2024. Multidisciplinary Respiratory Medicine 19 (1). https://doi.org/10.5826/mrm.2024.956.