Evaluation of screening tools for primary ciliary dyskinesia in Egypt: single center study

Evaluation of screening tools for primary ciliary dyskinesia in Egypt: single center study

Authors

  • Amr G. Elbanna Department of Pediatrics, Faculty of Medicine, Alexandria University, Alexandria, Egypt
  • Walaa Shoman Department of Pediatrics, Faculty of Medicine, Alexandria University, Alexandria, Egypt
  • Moushira A.R. Elheneidy Department of Histology and Cell Biology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
  • Ihab Elsawy Department of Pediatrics, Faculty of Medicine, Alexandria University, Alexandria, Egypt
  • Ahmad Kantar Pediatric Asthma and Cough Centre, Istituti Ospedalieri Bergamaschi University and Research Hospitals, Ponte San Pietro-Bergamo, Italy
  • Nader Fasseeh Department of Pediatrics, Faculty of Medicine, Alexandria University, Alexandria, Egypt

Keywords:

Primary ciliary dyskinesia, Screening, Egypt.

Abstract

Background: Primary ciliary dyskinesia (PCD) is a chronic respiratory illness that places significant strain on the healthcare system due to the complexity and expense of its diagnosis and treatment methods. The diagnostic process typically requires skilled technicians and an assortment of intricate, costly, and time-consuming approaches. Implementing screening tools can enhance efficiency by focusing the diagnostic process on those strongly suspected of having PCD. Tools such as the PCD Rule (PICADAR), North America Criteria Defined Clinical Features (NA-CDCF), the Clinical Index Score (CI), and the newly proposed CInew13 could potentially serve as useful screening tools. This study aims to examine the effectiveness of these tools individually, compare their performance against each other, and assess their results relative to prior research.

Methods: We conducted a diagnostic accuracy test on 83 Egyptian patients referred to Alexandria University Children’s Hospital for potential PCD diagnosis between January 2015 and December 2022. The scores obtained from the screening tools were calculated and assessed.

Results: Of the initial group, 10 patients were ruled out because they fit other diagnostic parameters. Forty-three cases received a confirmed diagnosis, while 30 did not. Notably, the confirmed cases consistently scored higher on our screening tools than those that remained unconfirmed (p <.001, for all tested scores). We used receiver operating characteristic curves to assess and compare the effectiveness of each tool. The NA-CDCF had the smallest area under curve 0.736 (95% confiedence interval 0.619-0.832); in contrast, the CI score had the largest 0.898 (95% confidence interval 0.808-0.957).

Conclusion: All the tools tested were effective in identifying suitable patients for PCD testing at statistically significant levels. However, the PICADAR and NA-CDCF scores’ performance did not significantly differ in the current study. The CI and CInew13 scores, on the other hand, outperformed both.

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Published

03-07-2024

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Original Research Articles

How to Cite

1.
Elbanna AG, Shoman W, Elheneidy MA, Elsawy I, Kantar A, Fasseeh N. Evaluation of screening tools for primary ciliary dyskinesia in Egypt: single center study. Multidiscip Respir Med [Internet]. 2024 Jul. 3 [cited 2024 Dec. 7];19(1). Available from: https://mrmjournal.org/index.php/mrm/article/view/966