Impact of biological therapies on laboratory outcomes and FEV1 in patients with severe eosinophilic asthma with chronic rhinosinusitis: a real-life study from Saudi Arabia

Impact of biological therapies on laboratory outcomes and FEV1 in patients with severe eosinophilic asthma with chronic rhinosinusitis: a real-life study from Saudi Arabia

Authors

  • Usama Abu Elhassan Assistant Professor of Pulmonary Medicine, Department of Pulmonary Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt. Consultant of Pulmonary Medicine, Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.
  • Salihah Y. Al-Mani Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.
  • Saad M. A. Alqahtani Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.
  • Medhat Elnamaky Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia. Department of Pulmonary Medicine, Faculty of Medicine, Al-Azhar University, Assiut Branch, Assiut, Egypt.
  • Abdulaziz Alfaifi Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.
  • Mohammed A. Alshehri 2Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.
  • Haneen A. Alasiri 2Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.
  • Ali S. Kadasah 2Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.
  • Abdullah Musleh Otorhinolaryngology Division, Surgery Department, College of Medicine, King Khalid University, Abha, Saudi Arabia.
  • Fawwaz A. Alshafa Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.
  • Muhammad S. S. Qureshi Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.
  • Abdulmohsen Y. Assiri Pharmaceutical Care Administration, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.
  • Abdulrahman I. Falqi Pharmaceutical Care Administration, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.
  • Bader I. Asiri Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.
  • Haider M. O. Ahmed Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.
  • Saleem Alshehry Internal Medicine Department, College of Medicine, King Khalid University, Abha, Saudi Arabia.
  • Abdelrahman M. Abdalla Department of Pulmonary Medicine, Faculty of Medicine, Beni Seuf University, Egypt. 2Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.

Keywords:

Severe asthma, Saudi Arabia, FEV1, Laboratory, Outcomes, Chronic rhinosinusitis, biologics

Abstract

Background: Few studies have addressed the effects of biological therapies on laboratory outcomes and changes in FEV1 in patients with severe asthma (SA) and chronic rhinosinusitis (CRS). We aimed to study the effect of three biological therapies on laboratory outcomes and FEV1 in Saudi Arabian patients with SA and CRS.

Methods: From March to September 2022, a retrospective observational cohort study was undertaken at the severe asthma clinics of the Armed Forces Hospital—Southern Region (AFHSR) and King Khalid University Hospital, Abha, Saudi Arabia, to delineate the effects of 3 biological therapies (benralizumab, dupilumab, and omalizumab) in adults with SA and concomitant CRS in terms of FEV1 and laboratory parameters (serum IgE and eosinophilic counts).

Results: Eighty patients were enrolled, with a mean age of 46.68. There were 45 (56%) females and 35 (44%) males. There were significant improvements in FEV1 and laboratory parameters (serum IgE and eosinophilic counts) after 6 &12 months of biological therapies compared to pre-biological therapies (p<0.001, each). The response was different among different biological therapies. The improvements in FEV1, serum IgE, and eosinophilic counts were manifest with benralizumab and dupilumab but not with omalizumab.

Conclusions: Results from the first study from two large Saudi Arabian tertiary centers for patients with severe asthma and chronic rhinosinusitis agree with and support those of worldwide real-life ones. One-year follow-up of patients with SA and CRS showed the effectiveness of benralizumab and dupilumab, but not omalizumab, regarding FEV1, serum IgE, and eosinophilic counts. Further prospective multicenter studies are warranted.  

 

Author Biographies

Usama Abu Elhassan, Assistant Professor of Pulmonary Medicine, Department of Pulmonary Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt. Consultant of Pulmonary Medicine, Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.

1Department of Pulmonary Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt. 2Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia. 

Salihah Y. Al-Mani, Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.

Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia

Saad M. A. Alqahtani, Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.

Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia

Medhat Elnamaky, Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia. Department of Pulmonary Medicine, Faculty of Medicine, Al-Azhar University, Assiut Branch, Assiut, Egypt.

Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia. Department of Pulmonary Medicine, Faculty of Medicine, Al-Azhar University, Assiut Branch, Assiut, Egypt

Abdulaziz Alfaifi, Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.

Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia

Mohammed A. Alshehri , 2Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.

Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia

Haneen A. Alasiri, 2Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.

Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia

Ali S. Kadasah, 2Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.

Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia

Abdullah Musleh, Otorhinolaryngology Division, Surgery Department, College of Medicine, King Khalid University, Abha, Saudi Arabia.

Otorhinolaryngology Division, Surgery Department, College of Medicine, King Khalid University, Abha, Saudi Arabia.

Fawwaz A. Alshafa, Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.

Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia

Muhammad S. S. Qureshi , Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.

Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia

Abdulmohsen Y. Assiri, Pharmaceutical Care Administration, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.

Pharmaceutical Care Administration, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia

Abdulrahman I. Falqi, Pharmaceutical Care Administration, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.

Pharmaceutical Care Administration, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia

Bader I. Asiri, Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.

Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia

Haider M. O. Ahmed, Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.

Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia

Saleem Alshehry, Internal Medicine Department, College of Medicine, King Khalid University, Abha, Saudi Arabia.

Internal Medicine Department, College of Medicine, King Khalid University, Abha, Saudi Arabia

Abdelrahman M. Abdalla, Department of Pulmonary Medicine, Faculty of Medicine, Beni Seuf University, Egypt. 2Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia.

Department of Pulmonary Medicine, Faculty of Medicine, Beni Seuf University,  Egypt. Department of Internal Medicine, Armed Forces Hospital Southern Region (AFHSR), Khamis Mushayt, Saudi Arabia

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09-09-2024

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1.
Abu Elhassan U, Al-Mani SY, Alqahtani SMA, Elnamaky M, Alfaifi A, Alshehri MA, et al. Impact of biological therapies on laboratory outcomes and FEV1 in patients with severe eosinophilic asthma with chronic rhinosinusitis: a real-life study from Saudi Arabia. Multidiscip Respir Med [Internet]. 2024 Sep. 9 [cited 2024 Dec. 8];19(1). Available from: https://mrmjournal.org/index.php/mrm/article/view/985