Efficacy and adherence of auto-CPAP therapy in patients with obstructive sleep apnea: a prospective study

Hang Dinh-Thi-Dieu; Anh Vo-Thi-Kim; Huong Tran-Van; Sy Duong-Quy

doi:10.4081/mrm.2020.468

Efficacy and adherence of auto-CPAP therapy in patients with obstructive sleep apnea: a prospective study

Authors

Hang Dinh-Thi-Dieu Hai Duong Medical Technical University, Hai Duong City
Anh Vo-Thi-Kim Department of Public Health, Thang Long University, Hanoi
Huong Tran-Van Department of Public Health, Thang Long University, Hanoi
Sy Duong-Quy Clinical Research and Sleep Lab Centers, Lam Dong Medical College, Da Lat City

DOI: https://doi.org/10.4081/mrm.2020.468

Keywords:

Obstructive sleep apnea, Apnea-hypopnea index, Epworth, Pichot, Auto-CPAP

Abstract

Introduction: The use of auto-continuous positive airway pressure (auto-CPAP) therapy has been recommended for subjects with moderate-to-severe obstructive sleep apnea (OSA) without significant comorbidities. This study is aimed at evaluating the efficacy and adherence of auto-CPAP therapy in subjects with OSA.

Methods: It was a perspective and descriptive study. All study subjects who had apnea-hypopnea index (AHI) >30/h, measured by polysomnography, were included. They were treated with auto-CPAP and followed-up for 6 months for evaluating the effect of CPAP-therapy on clinical and biological features and treatment adherence.

Results: One hundred and thirty-nine subjects with severe OSA were accepted for auto-CPAP therapy at inclusion. BMI was 28.4±3.8 kg/m²; neck and abdomen circumferences were 38.2±6.4 and 85.7±11.6. Epworth and Pichot scores were 18.4±6.3 and 28.3±4.5, respectively; AHI was 39±7/h and arousal index was 39±13/hour. At 6^th month, 96.4% of study subjects continued to use auto-CPAP-therapy within 6.5±2.4 hours/night. There was a significant correlation between the modification (Δ) of Epworth scores and (Δ) AHI after 3 and 6 months of auto-CPAP-therapy (R=0.568 and P=0.003; R=0.745 and P=0.002; respectively). At 6^th month follow-up, the main side effects of auto-CPAP were difficult sleeping, dry mouth or nose, skin marks or rashes, discomfortable breathing, and nasal congestion (36.1%, 32.0%, 20.8%, 16.0%, and 11.9%; respectively).

Conclusion: Auto-CPAP is effective in treatment of Vietnamese patients with severe OSA in short-term follow-up.

Author Biographies

Huong Tran-Van, Department of Public Health, Thang Long University, Hanoi

Hershey Medical Center, Penn State Medical College, Hershey, PA, USA

Sy Duong-Quy, Clinical Research and Sleep Lab Centers, Lam Dong Medical College, Da Lat City

Hershey Medical Center, Penn State Medical College, Hershey, PA, USA

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